Scientific Name: Manis javanica
Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Laurasiatheria-> Pholidota-> Manidae-> Manis
Summary: This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009] [NCBI] [Proteinatlas]
Data set information
Project | Date | Technology | Tissue | Condition | Cell | PMID/DOI |
---|---|---|---|---|---|---|
Vthunter_0035 | 2021.04 | 10X Genomics | Duodenum | Normal | 1482 | Link |
Vthunter_0036 | 2021.04 | 10X Genomics | Esophagus | Normal | 24581 | Link |
Vthunter_0037 | 2021.04 | 10X Genomics | Heart | Normal | 12958 | Link |
Vthunter_0038 | 2021.04 | 10X Genomics | Kidney | Normal | 4481 | Link |
Vthunter_0039 | 2021.04 | 10X Genomics | LargeIntestine | Normal | 3328 | Link |
Vthunter_0040 | 2021.04 | 10X Genomics | Liver | Normal | 5694 | Link |
Vthunter_0041 | 2021.04 | 10X Genomics | Lung | Normal | 13720 | Link |
Vthunter_0042 | 2021.04 | 10X Genomics | Spleen | Normal | 3207 | Link |
Vthunter_0043 | 2021.04 | 10X Genomics | Stomach | Normal | 12485 | Link |
Featureplot of receptors
Expression: Biased expression in skin (RPKM 64.2), esophagus (RPKM 38.3) and 8 other tissues